Project Updates

Ceftriaxone paper accepted

Author: Marya Lieberman

Congratulations to Sarah Bliese, whose paper on analysis of ceftriaxone via the 12-lane PAD was just accepted in Analytical Methods.  Sarah used principal component analysis (PCA) to differentiate good and bad products and even to figure out why a given product was bad quality.  

Graphical Abstract CeftriaxoneColor "bar codes" classify the products as good or bad.…

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No HPLC? No problem!

Author: Marya Lieberman

Nick Meyers' paper on quantitative analysis of beta lactams on a paper card was just accepted by Analytical Methods.  Congratulations Nick! The aPAD accuracy is about 5%, not quite as good as an HPLC, but then again, the aPAD doesn't cost $40,000.  

Apad Toc Jpg Full SizeThe more blue dots appear, the smaller the antibiotic content.…

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Madeline Smith won an outstanding poster award at the Gordon Conference

Author: Marya Lieberman

Madeline's poster was titled, "The chemoPAD: A Paper Analytical Device for Detection of Four Chemotherapy Drugs," and Ayenew Ashenef from Addis Ababa University is a co-author.  Congratulations to Madeline!  

 

2019 Madeline Smith Grc Poster Award

The 2019 Gordon Research Conference on Preclinical Form and Formulation for Drug Discovery focused on cutting edge research on the development, characterization and manufacture of formulations that span multiple modalities., such as …

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Kat Hayes and Vincent Schmitz awarded $30,000 in pitch competition

Author: Marya Lieberman

The Disease Diagnostic INventors Challenge provides funding to focus measurement science and engineering creativity at Purdue, IU, IBRI and Notre Dame on innovations with the potential to address unmet biomedical needs. Kathleen Hayes and Vincent Schmitz brought together the research strengths of the Whalen and Lieberman groups at Notre Dame to tackle the difficult task of detecting bad quality or fake oxytocin.  There is currently no field test available for oxytocin quality, and studies show that about 1 in 4 vials dispensed to women in Africa do not meet quality standards.  Good luck to these energetic first year grad students!…

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Heather DiLallo honored by St Mary's College

Author: Marya Lieberman

The 2019 Lumen Christi award was presented to Heather DiLallo, who has worked for many years with the PAD project at Saint Mary's. Heather is a Chemistry major who has worked to detect falsified medicines in Nepal and China through Toni Barstis's IRES program.  She is in the 5-year dual degree program, and will be continuing her engineering coursework next academic year at Notre Dame.  We look forward to seeing her around campus! …

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Good Guy Tom's

Author: Marya Lieberman

I'm at the icddr,b site in Bandarban, and sharing the facility with about 800 boxes of shoes donated by shoe company Tom's.  They promise that for every pair they sell in the US, they'll donate a pair of shoes to children in need.  Looks like they are following through.  The community health workers distribute the shoes when they're doing their other duties.  Photo coming later. …

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PADs in Bangladesh

Author: Marya Lieberman

Marya Lieberman gave a workshop about post-market surveillance for 40 staff members from the Directorate General of Drug Administration in Dhaka, Bangladesh, the National Control Lab, and WHO-PQM. 

The workshop included a fun project to evaluate the supply chain of a medicine which involved 28 neophytes analyzing samples from a fictional country.  The PAD reader box also made its first debut outside Notre Dame.  This smart PAD reader will be sited in Bandarban at the icddr,b field office, where a small sampling project will be based in 2019.    …

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Policy actions against falsified and substandard medicine

Author: Marya Lieberman

ASTMH Journal has a good review of policy options for combatting  falsified and substandard medicines--link here. 

Abstract:  Falsified and substandard medicines are associated with tens of thousands of deaths, mainly in young children in poor countries. Poor-quality drugs exact an annual economic toll of up to US$200 billion and contribute to the increasing peril of antimicrobial resistance. The WHO has emerged recently as the global leader in the battle against poor-quality drugs, and pharmaceutical companies have increased their roles in assuring the integrity of drug supply chains. Despite advances in drug quality surveillance and detection technology, more efforts are urgently required in research, policy, and field monitoring to halt the pandemic of bad drugs. In addition to strengthening international and national pharmaceutical governance, in part by national implementation of the Model Law on Medicines and Crime, a quantifiable Sustainable Development Goal target and an international convention to insure drug quality and safety are urgent priorities.…

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Thank you to USP!

Author: Marya Lieberman

In analytical chemistry, everything depends on access to high quality reference materials. The US Pharmacopeia donated over $5,000 worth of reference standards to the PAD project in 2019.  Thanks for this contribution to our work! 

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Oxford conference on Medicine Quality and Public Health

Author: Marya Lieberman

The Medicine Quality and Public Health conference at Oxford University had 200 participants from over 50 countries, including the Directors General of the Tanzanian and Nigerian drug regulatory agencies and academics, NGOs, WHO, and pharmaceutical companies.

Marya Lieberman and Philip Coyne attended and gave several presentations.  …

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Cartoon version of PAD project at MQPH meeting

Author: Marya Lieberman

At the Oxford MQPH conference, Marya Lieberman presented in a session titled Screening Technologies:  Will they Save the Day?  The talk was captured by the sketch artist.  Here we see a summary of how the PAD works and the results of the supply chain exercise that the 20 students in the short course obtained the previous week.  …

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