tag:padproject.nd.edu,2005:/project-updatesPaper Analytical Device Project | Project Updates2023-12-07T03:10:00-05:00tag:padproject.nd.edu,2005:News/1585882023-12-07T03:10:00-05:002023-12-07T03:15:22-05:00Fentanyl test strips have "blind spots" for detection of fentanyl analogs--Kat's paper is now published! <p>Fentanyl test strips are an important tool for detecting opioids that can cause fatal overdoses.</p>
<p>By testing over 200 fentanyl analogs with two brands of fentanyl test strips (FTS), Kathleen Hayes found that the test strips can detect many, but not all, fentanyl analogs.  The types of analogs that a given FTS can detect are related to the hapten used to elicit the strip's antibodies.  This work is now <a href="https://rdcu.be/dsXOM">published in Harm Reduction Journal</a>…</p><p>Fentanyl test strips are an important tool for detecting opioids that can cause fatal overdoses.</p>
<p>By testing over 200 fentanyl analogs with two brands of fentanyl test strips (FTS), Kathleen Hayes found that the test strips can detect many, but not all, fentanyl analogs. The types of analogs that a given FTS can detect are related to the hapten used to elicit the strip's antibodies. This work is now <a href="https://rdcu.be/dsXOM">published in Harm Reduction Journal</a>. </p>
<p>Carfentanil is a fentanyl analog 50 times stronger than fentanyl. In the photo below, one brand of test strips (BTNX) shows one red line which means it detects carfentanil, and the other brand shows two red lines, which means it does not. </p>
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<p> </p>Marya Liebermantag:padproject.nd.edu,2005:News/1570672023-10-06T19:09:10-04:002023-10-06T19:09:10-04:00Global problems with chemotherapy drug quality require global solutions; we think PADs can play a role<p><a href="https://www.thebureauinvestigates.com/stories/2023-10-06/new-test-in-the-works-to-catch-bad-cancer-drugs">Reporting from the Bureau of Investigative Journalism</a> features the chemoPAD project;  chemoPAD team members Dr. Paul Ndom, Prof. Marya Lieberman, and Prof. Ayenew Ashenef are quoted in the piece.  …</p><p><a href="https://www.thebureauinvestigates.com/stories/2023-10-06/new-test-in-the-works-to-catch-bad-cancer-drugs">Reporting from the Bureau of Investigative Journalism</a> features the chemoPAD project; chemoPAD team members Dr. Paul Ndom, Prof. Marya Lieberman, and Prof. Ayenew Ashenef are quoted in the piece. </p>Marya Liebermantag:padproject.nd.edu,2005:News/1565222023-09-18T13:54:00-04:002023-09-18T13:56:15-04:00Congratulations to Dr. Kathleen Hayes!<p>June 22, 2023--After defending her dissertation, "Methods for Pharmaceutical and Illicit Drug Analysis," Kathleen Hayes is now a PhD and will move on to Abbvie as a medical writer.  Good luck Kat, we will miss you!  </p>
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<figure class="image image-right"><img src="https://padproject.nd.edu/assets/539812/300x/2023_kathleen_kat_hayes_copy.jpeg" alt="2023 Kathleen Kat Hayes Copy">
<figcaption>2023 Kathleen Kat Hayes Copy</figcaption>…</figure><p>June 22, 2023--After defending her dissertation, "Methods for Pharmaceutical and Illicit Drug Analysis," Kathleen Hayes is now a PhD and will move on to Abbvie as a medical writer. Good luck Kat, we will miss you! </p>
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<figure class="image image-right"><img src="https://padproject.nd.edu/assets/539812/300x/2023_kathleen_kat_hayes_copy.jpeg" alt="2023 Kathleen Kat Hayes Copy">
<figcaption>2023 Kathleen Kat Hayes Copy</figcaption>
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<p> </p>Marya Liebermantag:padproject.nd.edu,2005:News/1565182023-09-18T12:08:58-04:002023-09-18T12:08:58-04:00Congratulations to Naxos Neighbors and Marya Lieberman, winners of ND Lucy Institute's $51,000 Next Changemaker Prize <p>Joanne Cogdell, CEO of harm reduction organization Naxos Neighbors, and her collaborator Marya Lieberman, University of Notre Dame, were awarded the 2023 Next Changemaker Award from the Lucy Institute for Data and Society. The award of $51,000 will support our efforts to find emerging hazards in street drugs such as fentanyl and fentanyl analogs, xylazine, benzodiazepines, and nitazines.  These superpotent opioids are associated with over 100 fatal overdose per year in this county and cause many other types of harm to people who use drugs, their families and friends, and the entire community.  …</p><p>Joanne Cogdell, CEO of harm reduction organization Naxos Neighbors, and her collaborator Marya Lieberman, University of Notre Dame, were awarded the 2023 Next Changemaker Award from the Lucy Institute for Data and Society. The award of $51,000 will support our efforts to find emerging hazards in street drugs such as fentanyl and fentanyl analogs, xylazine, benzodiazepines, and nitazines. These superpotent opioids are associated with over 100 fatal overdose per year in this county and cause many other types of harm to people who use drugs, their families and friends, and the entire community. </p>Marya Liebermantag:padproject.nd.edu,2005:News/1565142023-09-18T10:56:00-04:002023-09-18T10:58:35-04:00Lieberman group attends first Scientific Meeting for ChemoPAD project in Ethiopia<p>The goal of the ChemoPAD project is to use paper analytical devices to screen the quality of chemotherapy drugs in sub-Saharan Africa.  The team includes collaborators from seven institutions and five countries.  </p>
<ul>
<li>US: University of Notre Dame and University of North Carolina,</li>
<li>Ethiopia: Addis Ababa University</li>…</ul><p>The goal of the ChemoPAD project is to use paper analytical devices to screen the quality of chemotherapy drugs in sub-Saharan Africa. The team includes collaborators from seven institutions and five countries. </p>
<ul>
<li>US: University of Notre Dame and University of North Carolina,</li>
<li>Ethiopia: Addis Ababa University</li>
<li>Cameroon: Clinton Health Access Initiative</li>
<li>Malawi: Kamuzu College of Health Sciences and UNC Project Malawi</li>
<li>Kenya: Moi Teaching and Referral Hospital</li>
</ul>
<p>Graduate students Rachel Roller and Max Wilfinger attended the meeting and presented workshops and training sessions on a variety of topics. </p>
<figure class="image image-left"><img src="https://padproject.nd.edu/assets/539770/2023_july_21_marya_max_rachel_at_aau_ethiopia_small_cropped.jpeg" alt="2023 July 21 Marya Max Rachel At Aau Ethiopia Small Cropped" width="600" height="719">
<figcaption>2023 July 21 Marya Max Rachel At Aau Ethiopia </figcaption>
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<figcaption>2023 Nih Chemopad Sci Meeting At Efda </figcaption>
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<p>Part of the meeting took place at the Ethiopian Food and Drug Authority building</p>
<p> </p>Marya Liebermantag:padproject.nd.edu,2005:News/1565132023-09-18T10:41:00-04:002023-09-18T10:41:15-04:00Ola presents NIR project at NOBCChe<p>Olatunde Awosiji Awotunde presented a poster on "Combining orthogonal analytical techniques to identify substandard or falsified formulations of pharmaceuticals " at the 2023 NOBCChE meeting.  Congratulations to Ola on representing Notre Dame at this national event!  </p>
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<figure class="image image-left"><img src="https://padproject.nd.edu/assets/539766/2023_olatunde_at_nobcche_meeting.jpg" alt="2023 Olatunde At Nobcche Meeting" width="600" height="800">…</figure><p>Olatunde Awosiji Awotunde presented a poster on "Combining orthogonal analytical techniques to identify substandard or falsified formulations of pharmaceuticals " at the 2023 NOBCChE meeting. Congratulations to Ola on representing Notre Dame at this national event! </p>
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<figure class="image image-left"><img src="https://padproject.nd.edu/assets/539766/2023_olatunde_at_nobcche_meeting.jpg" alt="2023 Olatunde At Nobcche Meeting" width="600" height="800">
<figcaption>2023 Olatunde At Nobcche Meeting</figcaption>
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<p> </p>Marya Liebermantag:padproject.nd.edu,2005:News/1540652023-06-15T10:01:42-04:002023-06-15T10:01:42-04:00Congratulations to Olatunde Awosiji Awotunde and Ornella Joseph, who have both passed their OCE exams! <p>Ola and Ornella were admitted as PhD candidates in May of 2023, congratulations!    …</p><p>Ola and Ornella were admitted as PhD candidates in May of 2023, congratulations! </p>Marya Liebermantag:padproject.nd.edu,2005:News/1540642023-06-15T09:55:00-04:002023-06-15T09:55:14-04:00Heather Whitehead and Kathleen Hayes published in Forensic Chemistry, part 2<p>Congratulations to Heather and Kat--their manuscript, "Development and validation of a liquid chromatography tandem mass spectrometry method for the analysis of 53 benzodiazepines in illicit drug samples," was just accepted by Forensic Chemistry! This manuscript follows the earlier method for analysis of common drugs and drug metabolites published in 2022.  …</p><p>Congratulations to Heather and Kat--their manuscript, "Development and validation of a liquid chromatography tandem mass spectrometry method for the analysis of 53 benzodiazepines in illicit drug samples," was just accepted by Forensic Chemistry! This manuscript follows the earlier method for analysis of common drugs and drug metabolites published in 2022. </p>Marya Liebermantag:padproject.nd.edu,2005:News/1540622023-06-15T09:42:00-04:002023-06-15T09:42:28-04:00Congratulations to Dr. Heather Whitehead!<p>Heather Whitehead defended her PhD thesis March 30, 2023.  Congratulations to Dr. Whitehead as she moves on to take EPA by storm as an ORISE EPA Fellow!  …</p><p>Heather Whitehead defended her PhD thesis March 30, 2023. Congratulations to Dr. Whitehead as she moves on to take EPA by storm as an ORISE EPA Fellow! </p>Marya Liebermantag:padproject.nd.edu,2005:News/1529222023-05-02T08:52:00-04:002023-05-02T08:52:09-04:00PAD project is highlighed in C&E News!<p><a href="https://cendigitalmagazine.acs.org/2023/04/30/marya-liebermans-paper-drug-tests-promote-safety-in-low-resource-settings-2/content.html?utm_email+=E4AF54DAE45F652304B595C0B9">Interview in Chemical and Engineering News </a>highlights our group's work to detect substandard and falsified pharmaceuticals.  </p>
<p> …</p><p><a href="https://cendigitalmagazine.acs.org/2023/04/30/marya-liebermans-paper-drug-tests-promote-safety-in-low-resource-settings-2/content.html?utm_email+=E4AF54DAE45F652304B595C0B9">Interview in Chemical and Engineering News </a>highlights our group's work to detect substandard and falsified pharmaceuticals. </p>
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<p> </p>Marya Liebermantag:padproject.nd.edu,2005:News/1508902023-02-09T10:38:00-05:002023-03-04T10:42:24-05:00How does the Scott Test for cocaine work? <p>The Scott test has been used for over 50 years as a presumptive test for cocaine. It involves a series of reagent additions and color changes...and if it's not done and interpreted correctly, it can send innocent people to jail. This <a href="https://publcif.iucr.org/cifmoldb/tmp/vublclwkpublic/anim_225.gif">crystal structure</a> now published in Acta Cryst E gives insight into what's going on in the test. </p>
<p><a href="https://journals.iucr.org/e/issues/2023/03/00/zl5041/index.html">Bis(</a><a href="https://journals.iucr.org/e/issues/2023/03/00/zl5041/index.html"><em>N</em></a>,<a href="https://journals.iucr.org/e/issues/2023/03/00/zl5041/index.html"><em>N</em></a>-diethyl-4-methyl-4-piperazine-1-carboxamide) tetra­kis­(iso­thio­cyanato-κ<a href="https://journals.iucr.org/e/issues/2023/03/00/zl5041/index.html"><em>N</em></a>)­cobalt(II), a model compound for the blue color developed in the Scott test. Oliver, A. G., Lockwood, T.-L. E., Zinna, J. & Lieberman, M. (2023). Acta Cryst. E79, 163-166</p><figure class="image-left"><img alt="Two molecules of a protonated tertiary amine ion pair with the Co(NCS)4 di-anion; this structure is a model for the blue coloration in the Scott test for cocaine." height="296" src="https://padproject.nd.edu/assets/503477/screen_shot_2023_02_09_at_10.26.23_am.png" width="343">
<figcaption>Two molecules of a protonated tertiary amine ion pair with the Co(NCS)4 di-anion; this structure is a model for the blue coloration in the Scott test for cocaine.</figcaption>
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<p>Crystal structure of the blue product produced by mixing a protonated tertiary amine, diethylcarbamazine citrate, with cobalt thiocyanate. The blue color comes from the tetrahedral [Co(NCS)<sub>4</sub>]<sup>2-</sup> di-anion, which forms a hydrophobic ion pair with the protonated tertiary amine. In this paper, we used stoichiometric quantities of cobalt and thiocyanate to form the tetrahedral di-anion, but it can also form by disproportionation of Co(SCN)<sub>2</sub> in water. </p>
<p>Many other quaternary, tertiary, and bulky secondary amines give blue precipitates when mixed with Co(SCN)<sub>2</sub>. This chemistry is the basis for the <strong>Scott Test for cocaine</strong>. The formation of the [Co(NCS)<sub>4</sub>]<sup>2-</sup> di-anion depends on the pH. Low pH can protonate the thiocyanate anions and release pink aqueous Co(II) cations, which is why addition of 1M HCl in the Scott test makes the blue color turn pink. When a hydrophobic solvent such as chloroform is added and a suitable hydrophobic protonated amine is available, the Co(NCS)<sub>4</sub>]<sup>2-</sup> di-anion can reform in the organic layer, generating a blue color in the chloroform. </p>Marya Liebermantag:padproject.nd.edu,2005:News/1508832023-02-09T10:22:00-05:002023-02-09T10:22:47-05:00Heather Whitehead and Kathleen Hayes published in Forensic Chemistry<p>This paper shares a tandem mass spectroscopy method for quantitative analysis of 22 drugs and drug metabolites. The samples were harvested from used idPADs;  we used this method, along with fentanyl and benzo test strips, to analyze 124 samples of illicit drugs collected from the Chicago area in 2021-2022.  …</p><p>This paper shares a tandem mass spectroscopy method for quantitative analysis of 22 drugs and drug metabolites. The samples were harvested from used idPADs; we used this method, along with fentanyl and benzo test strips, to analyze 124 samples of illicit drugs collected from the Chicago area in 2021-2022. </p>
<p>Heather D. Whitehead, Kathleen L. Hayes, James A. Swartz, Elizabeth Prete, Lisa Robison-Taylor, Mary Ellen Mackesy-Amiti, Antonio D. Jimenez, Marya Lieberman, "Validated method for the analysis of 22 illicit drugs and their metabolites via liquid chromatography tandem mass spectrometry (LC-MS/MS) in illicit drug samples collected in Chicago, IL"<br>
Forensic Chemistry, 2023, 100475, https://doi.org/10.1016/j.forc.2023.100475.</p>
<p>Abstract: Drug checking services are being utilized worldwide to provide people who use drugs information on the composition and contents of their drugs as a tool for harm reduction and accidental overdose prevention. Existing drug checking services use a variety of techniques including immunoassay strips and spectroscopic techniques like FTIR and Raman. Few services utilize LC-MS based methods for primary or secondary analysis and few methods exist for direct analysis of illicit drugs. To address this, an LC-MS/MS method was developed for 22 illicit drugs and cutting agents using LC-MS/MS with application to 124 illicit drug samples that were collected from Chicago, IL. Samples were also analyzed using fentanyl and benzodiazepine immunoassay test strips. Fentanyl test strips gave a positive result for 86% of samples with only one sample showing a positive result on a benzodiazepine test strip. LC-MS/MS analysis of samples show that opioids were the most commonly quantified in 96% of samples, followed by stimulants at 12% and benzodiazepines at 1%. Fentanyl was measured in 91% of samples, co-occurring with heroin in 58% of opioid-containing samples. A comparison of the gold-standard LC-MS/MS results to fentanyl test strips shows a high level of accuracy for the fentanyl test strips, with just 5% of samples being classified as false negatives and no false positives. These results demonstrate the strengths and benefits of LC-MS/MS when incorporated as a secondary analysis tool for drug checking.</p>Marya Liebermantag:padproject.nd.edu,2005:News/1508822023-02-09T10:03:43-05:002023-02-09T10:04:56-05:00Kathleen Hayes and Marya Lieberman published in Nature Methods Reviews Primers<p>This commentary article, "<a href="https://www.nature.com/articles/s43586-023-00197-z">Considerations for the design and implementation of point-of-care technology for use in low- and middle-income countries</a>," uses the PAD project to reflect on why some technologies can be implemented in low-resource settings, and others never make it out of the lab.  …</p><p>This commentary article, "<a href="https://www.nature.com/articles/s43586-023-00197-z">Considerations for the design and implementation of point-of-care technology for use in low- and middle-income countries</a>," uses the PAD project to reflect on why some technologies can be implemented in low-resource settings, and others never make it out of the lab. </p>
<p>"Designing technology for point-of-care use in low- and middle-income countries requires understanding of the underlying barriers that contribute to recalcitrant global problems. The only way to understand those barriers is to work with local experts, otherwise you may wind up solving the wrong problem."</p>Marya Liebermantag:padproject.nd.edu,2005:News/1500132022-12-21T13:09:35-05:002022-12-21T13:09:35-05:00Kim Frederick's paper about teaching analytical method design with MICRO PADs is out! <figure class="image-default"><img alt="Images Large Ed2c00370 0006" height="368" src="https://padproject.nd.edu/assets/498261/images_large_ed2c00370_0006.jpeg" width="600"></figure>
<p><a href="https://pubs.acs.org/doi/10.1021/acs.jchemed.2c00370"><em>J. Chem. Educ.</em> 2022, 99, 12, 4024-4031</a></p>
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<p><a href="https://pubs.acs.org/doi/10.1021/acs.jchemed.2c00370"><em>J. Chem. Educ.</em> 2022, 99, 12, 4024-4031</a></p>
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<p> </p>Marya Liebermantag:padproject.nd.edu,2005:News/1498952022-12-14T19:10:00-05:002022-12-14T19:13:31-05:00A conversation with Marya Lieberman--ACS Central Science<p>This interview was just published in ACS Central Science.  </p>
<p><a href="https://pubs.acs.org/doi/10.1021/acscentsci.2c01446">Check it out!</a>  …</p><p>This interview was just published in ACS Central Science. </p>
<p><a href="https://pubs.acs.org/doi/10.1021/acscentsci.2c01446">Check it out!</a> </p>Marya Liebermantag:padproject.nd.edu,2005:News/1482942022-10-04T16:40:00-04:002022-10-04T16:40:10-04:00Turkey Run 2022<figure class="image-right"><img alt="2022 Group At Turkey Run Analytical Conference Heather And Kat Organizers" src="https://padproject.nd.edu/assets/488067/2022_group_at_turkey_run_analytical_conference_heather_and_kat_organizers.jpg">
<figcaption>The Lieberman group takes a moment to relax at Turkey Run</figcaption>
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<p>Turkey Run Analytical Conference 2022 was held at Turkey Run State Park in Indiana, and attracted researchers from Indiana, Ohio, and Illinois. In addition to Heather, Kat, Alyssa, Rachel, and Ornella, undergraduates Devena and Sarah presented posters, and Yukun from the Peaslee group also gave a poster. Congratulations to Heather Whitehead and Kathleen Hayes for organizing a great scientific meeting!  …</p><figure class="image-right"><img alt="2022 Group At Turkey Run Analytical Conference Heather And Kat Organizers" src="https://padproject.nd.edu/assets/488067/2022_group_at_turkey_run_analytical_conference_heather_and_kat_organizers.jpg">
<figcaption>The Lieberman group takes a moment to relax at Turkey Run</figcaption>
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<p>Turkey Run Analytical Conference 2022 was held at Turkey Run State Park in Indiana, and attracted researchers from Indiana, Ohio, and Illinois. In addition to Heather, Kat, Alyssa, Rachel, and Ornella, undergraduates Devena and Sarah presented posters, and Yukun from the Peaslee group also gave a poster. Congratulations to Heather Whitehead and Kathleen Hayes for organizing a great scientific meeting! </p>Marya Liebermantag:padproject.nd.edu,2005:News/1482932022-10-04T16:35:00-04:002022-10-04T16:35:28-04:00Congratulations to Alyssa Wicks for passing her ARP!<p>Alyssa signed up for an early ARP time and passed with flying colors!  Congratulations, Alyssa.  …</p><p>Alyssa signed up for an early ARP time and passed with flying colors! Congratulations, Alyssa. </p>Marya Liebermantag:padproject.nd.edu,2005:News/1476492022-09-06T16:07:36-04:002022-09-06T16:07:36-04:00Congratulations to Olatunde Awosiji Awotunde, Nicholas Roseboom, and Jin Cai! <p>Discrimination of Substandard and Falsified Formulations from Genuine Pharmaceuticals Using NIR Spectra and Machine Learning</p>
<p>Near-infrared (NIR) spectroscopy is a low-cost analytical tool for rapid characterization of pharmaceuticals. Usually, it's necessary to build up a "library" of NIR spectra from authentic products in order to identify real and fake formulations.  In this paper, we developed a simple training method that uses binary mixtures of a pharmaceutical (acetaminophen) with two different cutting agents, and used several different data analysis models to extrapolate the training samples to real and fake samples of popular brands of acetaminophen tablets.   While none of the models was able to correctly classify all the samples, a simple voting algorithm was able to compensate for the weaknesses of the models and classify 93% of the samples correctly.  …</p><p>Discrimination of Substandard and Falsified Formulations from Genuine Pharmaceuticals Using NIR Spectra and Machine Learning</p>
<p>Near-infrared (NIR) spectroscopy is a low-cost analytical tool for rapid characterization of pharmaceuticals. Usually, it's necessary to build up a "library" of NIR spectra from authentic products in order to identify real and fake formulations. In this paper, we developed a simple training method that uses binary mixtures of a pharmaceutical (acetaminophen) with two different cutting agents, and used several different data analysis models to extrapolate the training samples to real and fake samples of popular brands of acetaminophen tablets. While none of the models was able to correctly classify all the samples, a simple voting algorithm was able to compensate for the weaknesses of the models and classify 93% of the samples correctly. </p>
<p>Graduate student Olatunde Awotunde was the lead author, working with researchers at Precise Software Solutions and with undergraduates Nicholas Roseboom and Jin Cai at Notre Dame. </p>
<p><a href="https://doi.org/10.1021/acs.analchem.2c00998" title="DOI URL">https://doi.org/10.1021/acs.analchem.2c00998</a></p>
<p> </p>Marya Liebermantag:padproject.nd.edu,2005:News/1472202022-08-15T15:07:04-04:002022-08-15T15:07:04-04:00Heather's paper selected as one of top 5 for 2021 by ACS Environmental Science and Technology<p>Congratulations to Heather (and Meghanne Tighe!) for this recognition of the impact of the<a href="https://chemistry.nd.edu/news/study-about-pfas-in-cosmetics-gains-distinction-with-2021-best-paper-award/"> paper,</a> which evaluated levels of per-fluorinated organic compounds in cosmetics.  …</p><p>Congratulations to Heather (and Meghanne Tighe!) for this recognition of the impact of the<a href="https://chemistry.nd.edu/news/study-about-pfas-in-cosmetics-gains-distinction-with-2021-best-paper-award/"> paper,</a> which evaluated levels of per-fluorinated organic compounds in cosmetics. </p>Marya Liebermantag:padproject.nd.edu,2005:News/1470042022-08-01T16:05:00-04:002022-08-01T16:05:00-04:00New system for tracking DPAL samples and data piloted<p>Working with the ARTiFACT Verify team, we are developing a system to monitor every stage of post-market surveillance, from sample collection to assay reports and dashboarding.  The <a href="https://artifacts.ai/proof-of-concept-provides-pathway-to-address-problem-of-substandard-and-falsified-drugs/">pilot of the Verify system</a>…</p><p>Working with the ARTiFACT Verify team, we are developing a system to monitor every stage of post-market surveillance, from sample collection to assay reports and dashboarding. The <a href="https://artifacts.ai/proof-of-concept-provides-pathway-to-address-problem-of-substandard-and-falsified-drugs/">pilot of the Verify system </a>underwent a live test in July, with participation from Prof. Ayenew Ashenef at Addis Ababa University, Prof. Tim Johann at Roanoke College, and the Lieberman group at Notre Dame. The pilot shows that the system can track sample provenance, metadata, and chain of custody in addition to recording PAD test results and HPLC assay data and QA/QC reports. Members of the DPAL network and our field partners in Malawi and Kenya are invited to join the next stage of development of this system, with scaleup training starting in early August. </p>Marya Lieberman